Endocrine Abstracts

Introduction: A precisely measured corticoid level is important for decision-making in daily clinical practice. These levels can be influenced in the pre-analytical phase, when the effect of stress, timing, and diet can be important.The aim of this study was to elucidate optimal conditions for blood sampling as well as the choice of analytical methods, which they will be used in measuring of corticoids.Methods: By studying ten wome...

We know that non-severe hypoglycaemia (SH) should be treated with the immediate intake of 15–20 g of oral glucose, there are no data according to our knowledge in the current literature for the dose of glucose that is necessary to inject in SH. We have analysed retrospectively the treatment of pre hospital SHs as reported after an emergency call for intervention. Our primary objective was to know the dose of the given glucose and our secondary objective was to know the fa...

Introduction: Latent toxoplasmosis, a zoonosis caused by protozoan Toxoplasma gondii, is the most widespread human parasitosis in developed countries (prevalence 20–80%). Upon infection, T. gondii stays in human organism lifelong. It has been linked to several autoimmune diseases, including autoimmune thyroid disease (AITD). The aim of our study was to assess the impact of latent T. gondii infection on the prevalence of AITD in pregnancy with re...

Adiponectin is a protein hormone mainly produced by adipocytes. It plays an essential role in the regulation of lipid and carbohydrate metabolisms. Adiponectin mediates its effects through mainly two receptors named AdipoR1 and AdipoR2. Some evidence in rodent and domestic animals suggests that adiponectin could also regulate female fertility and more particularly ovarian functions. However, its role in human ovary has never been investigated. The objectives of the present stu...

Stress is increasingly pervasive in modern society and an unavoidable stimulus to the human organism. Stressors, whether of social or physical type, activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the upregulation of glucocorticoid levels and, in some cases, its de novo biosynthesis. Aside from HPA axis regulation, corticosteroids modulate the immune response to inflammation and affect whole-body metabolism. Despite numerous studies using traditional GC-MS...

Familial Partial Lipodystrophy Syndromes (FPLD) are rare diseases characterized by partial lack of subcutaneous fat resulting in a severe metabolic syndrome and cardiovascular complications. Besides premature cell senescence, 2 main mechanisms are involved in FPLD: impaired adipocyte differentiation and lipid droplet, corresponding to two of the main causes of FPLD: LMNA-related FPLD2 and PLIN-related FPLD4. The objective of this study was to compare the clin...

As genetic and environmental components contribute to the PCOS expression, we compared levels of endocrine disruptors, steroid hormones, cytokines, and metabolic parameters in twenty healthy, nine normal-weight PCOS women, and ten obese PCOS women. Steroid hormones, bisphenols (BPA, BPS, BPF, BPAF) and parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-parabens) were measured by liquid chromatography-tandem mass spectrometry. Differences between the groups were assessed using ...

Stress is increasingly pervasive in modern society and an unavoidable stimulus to the human organism. Stressors, whether of social or physical type, activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the upregulation of glucocorticoid levels and, in some cases, its de novo biosynthesis. Aside from HPA axis regulation, corticosteroids also modulate the immune response to inflammation and affect the whole-body metabolism. Accurate quantification of endogenous s...

Context: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, were long considered infertile. Testicular sperm extraction (TESE) now allows some of these patients to access fatherhood. The predictive factors for success, however, remain unknown.Patients and methods: Non-mosaic KS patients with azoospermia or severe cryptozoospermia on two semen analyses without any other spermatogenesis disorder were included. They were sorted into two age ...

Introduction: Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was...